Effects of Qidantongmai tablets on gene expression of intercellular adhesion moleculeª²1 and vascular cell adhesion moleculeª²1 in artery vessels of experimental arterosclerotic rats

    MA Aiª²Ling, WANG Zongª²Ren, ZHENG Jin, ZHANG Zhongª²Hai, SU Mingª²Quan, YUE Qiaoª²Hong, MA Jing1, MA Shiª²Ping

    1Department of Traditional Chinese Medicine, 2Department of Clinical Laboratories, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To investigate the effects of QiDanTongMai Tablets (QDTMT) on the gene expression of intercellular adhesion moleculeª²1 and vascular cell adhesion moleculeª²1 in artery vessel of experimental arterosclerotic rats. METHODS: Seventyª²two healthy male SD rats were randomly divided into 6 groups of 12 rats per group: model group, control group, simvastatin group, QDTMT low dosage group (QDTMTL), QDTMT moderate dosage group (QDTMTM), QDTMT high dosage group (QDTMTH). The model of arterosclerosis (AS) was established by feeding high cholesterol diet and vitamin D3. Halfª²quantitative reverse transcription polymerase chain reaction (RTª²PCR) was used to detect ICAMª²1 and VCAMª²1 gene expression in artery vessel. The changes of gene expression of ICAMª²1 and VCAMª²1 in artery vessels in each group were analyzed. RESULTS: ICAMª²1 and VCAMª²1 mRNA expression levels in the model group were significantly higher than those of control group (P<0.01). While compared with model group, the ICAMª²1 and VCAMª²1 mRNA expression levels in each medicated group were significantly lower (P<0.01 or P<0.05). QDTMTH group had significantly better results than QDTMTL group (P<0.05). CONCLUSION: QDTMT can downregualte the gene expression of ICAMª²1 and VCAMª²1 in artery vessels of experimental arterosclerotic rats, which may account for the anti arteriosclerosis effects of QDTMT. ......