Relationship between serum tumor necrosis factorª²¦Á and ulcerative colitis

    JIA Baiª²Ling, HOU Xiaoª²Hua

    1Department of Gastroenterology, Xiehe Hospital, Tongji Medical College, Huazhong Technolog University, Wuhan 430022, China, 2Department of Gastroenterology, Henan Provincial People¡¯s Hospital, Zhengzhou 450003, China

    ¡¾Abstract¡¿ AIM: To determine the levels of tumor necrosis factorª²¦Á(TNFª²¦Á) in serum of patients with ulcerative colitis (UC) and to study the relationship between TNFª²¦Á levels and the active degree and area of lesion of UC. METHODS: The sera were collected from 56 patients with UC and the level of TNFª²¦Á was measured by ELISA. TNFª²¦Á was also measured in normal blood donors as control. RESULTS: The levels of serum TNFª²¦Á of patients with UC in active stage were (227.5¡À39.5) ng/L, significantly higher than those of patients with UC in inactive stage [(131.2¡À37.8) ng/L] and normal control [(120.1¡À36.4) ng/L] (P<0.01). The levels of serum TNFª²¦Á with whole colon disorder [(298.2¡À30.9) ng/L] were higher than those with rectum sigmoid lesion [(166.4¡À35.3) ng/L] and left colon disorder [(153.8¡À34.3) ng/L] (P<0.01). CONCLUSION: The changing levels of serum TNFª²¦Á may be related to the development of UC and can be used as an index for the disease. ......