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    Association of polymorphism of Nª²acetyltransferase gene with susceptibility to colorectal cancer in Han nationality of Hebei province

    HE Luª²Jun, JIANG Lingª²Ling, LIU Jingª²Shan, SHI Cuiª²Ying

    1Department of Biochemistry, Hebei Medical University, Shijiazhuang 050017, China, 2Hebei Provincial Blood Center, Shijiazhuang 050017, China

    ¡¾Abstract¡¿ AIM: To investigate the relationship between polymorphism of Nª²acetyltransferase 2 (NAT2) gene and susceptibility to colorectal cancer in Han nationality of Hebei province, China. METHODS: A caseª²control study was performed in 83 patients with colorectal cancer and 83 control subjects. The genotypes of NAT2 were determined by polymerase chain reactionª²restriction fragment length polymorphism(PCRª²RFLP) assay. RESULTS: There was no significant differences in fastª²acetylator genotypes between patients and control subjects(¦Ö2=0.1365, P=0.7118). The frequencies of genotype Wt/M2 were higher (¦Ö2=10.2176, P=0.0014) in patients (42.2%) as compared with control subjects(19.3%). If the Odds ratio (OR) for Wt/Wt was 1, OR for genotype Wt/M2 was 3.21 (95% CI: 1.33-7.76); OR for Wt/M1 was 0.37<1 (95% CI: 0.04-3.61); OR for Wt/M3 was 0.98<1 (95% CI: 0.38-2.51); OR for other genotypes (Mx/Mx x=1,2,3,4) was 1.32 (95% CI: 0.53-3.29), including 1. CONCLUSION: These data suggest that genotype Wt/M2 may be a risk factor of colorectal cancer in Han nationality of Hebei province, China. ......