Effects of apolipoprotein E polmorphism on efficacy of Tating drugs in treating coronary heart disease

    ZHANG Liª²Li, L¦a Anª²Lin, JIA Guoª²Liang, WANG Haiª²Chang

    Department of Cardiovasology, Xijing Hospital, Fourth Military Medical University, Xi¡¯an 710033, China

    ¡¾Abstract¡¿ AIM: To explore the relationship between apolipoprotein E (apoE) polmorphism and the efficacy of Tating drugs in regulating lipid and eliminating atherosclerosis in treating coronary heart disease. METHODS: One hundred and twentyª²one coronary heart disease (CHD) patients¡¯ genotypes were detected by PCRª²RELP and the serum lipid levels were measured by routine methods. The diagnostic standards for coronary atherosclerotic stenosis were established by QCA. RESULTS: Five genotypes of apoE E2/2, E 2/3, E3/3, E3/4 and E4/4 were detected and the plasma lipid level total cholesterol (TC) and low density lipoprotein (Ldlª²c) and high density lipoprotein (Hdlc) markedly decreased (P<0.01) in patients with CHD. Among the 5 genotypes, apo E2/2 + E2/3 and E3/3 had significantly better efficacy than apo E3/4+E4/4 (P<0.05). CONCLUSION: Our results suggest that apo E gene polmorphism is closely associated with plasma lipid regulation and coronary atherosclerosis elimination. ......