Relation between gradual reduction of PaO2 and dynamic changes of NO and ET of liver and brain

    WANG Ling, LIU Junª²Hong, ZHANG Jianª²Long, OU Xiaoª²Peng

    1Department of Internal Medicine, Medical Team of Urumqi Military Academy, Xinjiang, Urumqi, 830002, 2Examine Station of Medicion and Instrument,The United Logistics Department of Xinjiang Military Region, Xingjiang Urumqi 830000, 3Department of Pathophysiology, Xinjiang Medical University, Xinjiang Urumqi, 4Department of Clinical Medicine, S1CA University

    ¡¾Abstract¡¿AIM: To investigate the dynamic changes of levels of No and ET of liver and brain during the gradual reduction of PaO2 in rabbits so as to provide theoretic basis for secondary damage of other organs in the acute lung injure. METHODS: The RDS of rabbits was established by injecting OA in vein. The PaO2, NO and ET of liver and brain were detected and the ultramicrostructure of the liver and brain was observed under the electron microscope. RESULTS: PaO2, MABP of OA groups decreased. The levels of NOS in the liver and NO in the brain increased in OA 30 min group (P<0.01), but it decreased in 60 min and later groups (P<0.01). The levels of ET in the liver increased in 30 min and 90 min groups (P<0.01) but decreased in 120 min group. The level of ET in the brain decreased in 30 min group (P<0.01) and increased in 60 min and later groups (P<0.05). The ultramicrostructure of the liver and the brain changed under the electron microscope in OA 90 min and 120 min groups. CONCLUSION: The liver and brain are damaged secondarily during RDS in the rabbits and the damage is associated with the reduction of PaO2 and MABP and the levels of NOS and ET. ......