乳腺肿瘤__(期刊论文)

bag1及bcl2基因产物在乳腺癌组织中的表达及意义

http://www.100md.com 《第四军医大学学报》 2003年第7期

乳腺肿瘤,,bag1；bcl2；免疫组化；乳腺肿瘤；凋亡,0引言,1对象和方法,2结果,3讨论,【参考文献】

     (第四军医大学西京医院：血管内分泌外科，病理科，陕西西安 710033)

    Expression and significance of apoptotic gene bag1 and bcl2 in breast cancer

    WANG Ling, YUN Jun, MA FuCheng, LI Qing

    Department of Vascular and Endocrine Surgery, Department of Pathology,Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To evaluate bag1 and bcl2 expressions in breast cancer and to evaluate their clinical significance. METHODS: bcl2 and bag1 expressions were studied by immunohistochemical StreptavidinBiotinPeroxidaseComplex (SABC) methods in 100 samples of breast cancer tissues, 10 normal breast tissues and in 10 benign tumor tissues, and their clinical significance were analyzed. RESULTS: The positive rate of bag1 expression among breast cancer, benign tumor and normal tissues were 85.0%, 10.0% and 10.0% respectively and significant difference was observed (P<0.05). However, the positive rate of bag1 expression was not related to the pathologic grades and the different clinical types (P>0.05). The positive rate of bcl2 expression among breast cancer, benign tumor and normal tissues were 46.0%, 20.0% and 20.0% respectively and significant difference was observed (P<0.05). The positive rate of bcl2 expression was not related to the pathologic grades and the different clinical types (P>0.05). CONCLUSIONS: There is an over expression of bag1 and low expression of bcl2 in breast cancer. The positive rate of bcl2 and bag1 expression is not related to the pathologic grades and the different clinical types. bag1 and bcl2 may serve as a biomarker in early diagnosis of breast cancer. ......

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