曲张静脉壁_____曲张静脉壁；结缔组织；胶原

人体正常和曲张的大隐静脉中胶原亚型的比较

http://www.100md.com 《第四军医大学学报》 2003年第8期

曲张静脉壁,,曲张静脉壁；结缔组织；胶原,0引言,1对象和方法,2结果,3讨论,【参考文献】

     (第四军医大学西京医院血管外科，陕西西安 710033，安徽中医学院第二附属医院普外科，安徽合肥 230061)

    Collagen subtype pattern in normal and varicose saphenous veins in humans

    WANG Ling，LI NanLin, ZHANG Zhen

    Department of Vascular Surgery, Xijing Hospital,Fourth Military Medical University,Xian 710033,China,Department of General Surgery, Second Affiliated Hospital,Anhui College of Traditional Chinese Medicine,Hefei 230061,China

    【Abstract】 AIM: To determine the collagen subtype pattern in the greater saphenous vein of the lower limbs obtained from 21 normal and 37 varicose subjects and to compare the affected and unaffected segments. METHODS: Following elastase pretreatment and partial pepsin digestion, typeⅠ, Ⅲ & Ⅴ collagens were extracted selectively by differential salt precipitation and measured quantitatively in samples obtained from normal and varicose saphenous veins. RESULTS: Significant elevations of water (water content were 78% and 80% respectively P<005) and collagen typeⅠ(P<001) content in varicose veins (both affected and unaffected segments) were observed as compared with those in normal saphenous veins. The content of collagen type Ⅲ and collagen type Ⅴ in varicose veins was found to be slightly reduced as compared with that in normal veins and as a result the CⅠ/(CⅢ+CⅤ)ratio in varicose veins increased significantly (CI content was (13±1)%, P<005;CⅢ plus CⅤ content were (19±05)% and (25±06)% respectively, P<001) as compared with in normal veins. CONCLUSION： The elevation of the CⅠ/(CⅢ+CⅤ)ratio in varicose veins (P<001) may result in the considerable weakening of the venous wall, which supports the “weak wall” theory of varicose vein etiology. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/02/19/87/21/34.htm

您现在查看是摘要页，全文长 11550 字符。