肿瘤_____干扰素；_NGR；_肿瘤

融合蛋白IFNα2bNGR 在荷瘤小鼠体内的肿瘤局部分布及组织定位

http://www.100md.com 《第四军医大学学报》 2004年第15期

肿瘤,,干扰素；,NGR；,肿瘤,；分布,融合蛋白IFNα2bNGR在荷瘤小鼠体内的肿瘤局部分布及组织定位,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Distribution in tumor location and tissue position of fusion protein IFNα2bNGR in tumorbearing murine

    LIU Lei, MENG JieRu, ZHAO Ning, YAN Zhen, ZHANG YingQi

    Biotechnology Center, Fourth Military Medical University, Xi’an 710033, China

    【Abstract】 AIM: To study the distribution of fusion protein IFNα2bNGR in different tissues of a murine tumor model. METHODS: Tumor models were treated by intravenous injection of IFNα2b or IFNα2bNGR solutions and the concentration of IFN was measured using ELISA. The distribution was characterized by immunohistochemical methods. RESULTS: In the group of IFNα2b, the concentration of IFN in the murine serum was (250±65) ng/L and it was lower than 78 ng/L in tumor tissues. The concentration of IFN was (255±61) ng/L in serum and (191±70) ng/L in tumor tissues of the group of IFNα2bNGR. Immunohistochemical assay proved the binding of IFNα2bNGR to tumor vasculature walls and tissue spaces. CONCLUSION: Fusion protein IFNα2bNGR can be targeted to tumor and the binding sites are on vascular walls. ......

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