星形细胞肿瘤__(期刊论文)

星形细胞肿瘤组织中核因子κB的表达与肿瘤增殖

http://www.100md.com 《第四军医大学学报》 2003年第7期

星形细胞肿瘤,,核因子κB；细胞周期素D1；细胞增殖核抗原；星形细胞肿瘤；免疫组织化学,0引言,1材料和方法,2结果,3讨论,【参考文献】

     (武汉大学中南医院神经外科，湖北武汉 430071)

    NFκB expression in the astrocytic tumors and its relation to tumor proliferation

    CHEN BaoDong, YUAN XianHou, JIANG PuCha，CHEN WeiGuo, WEN ZhiHua

    Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, China

    【Abstract】 AIM: To evaluate the significance of nuclear factor kappa B (NFκB) p65 protein expression and their relationship with tumor proliferation. METHODS: The expression of NFκB p65 protein, cyclin D1 protein and proliferating cell nuclear antigen (PCNA) protein in 64 cases of astrocytic tumors and 10 cases of normal brain tissue were studied immunohistochemically. RESULTS: None of the normal tissues exhibited NFκB p65, cyclin D1 protein. In contrast, 35 of 64 astrocytic tumor specimens were positive for NFκB p65 protein with a 54.7% positive rate (P<0.01), and 27 of 64 astrocytic tumor specimens were positive for cyclin D1 protein with a 42.2% positive rate (P<0.01), the labeling index of PCNA protein were 2.2%-80.5%. Normal brain tissue were negative or of low expression for PCNA protein. The NFκB p65 protein, cyclin D1 and PCNA protein expression were correlated to the differentiation (P<0.05).The expression of NFκB p65 was closely related with the expression of cyclin D1 and PCNA. CONCLUSION: NFκB p65 is a new oncogenic protein related to the astrocytic tumors. NFκB p65 upregulates the expression of cyclin D1 and PCNA, then leads to tumor cell malignant proliferation and tumor occurrence. ......

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