心力衰竭__(期刊论文)

比索洛尔对充血性心衰患者CGRP和ET1浓度及心脏功能的影响

http://www.100md.com 《第四军医大学学报》 2003年第7期

心力衰竭,,比索洛尔；心力衰竭，充血性；降钙素基因相关肽；内皮素1；心脏射血分数,0引言,1材料和方法,2结果,3讨论,【参考文

     (第四军医大学西京医院：心血管内科，综合诊疗科心电图室，陕西西安 710033)

    Effects of bisoprolol on plasma calcitonin gene related peptide, endothlin and heart function in patients with chronic heart failure

    WANG HaiYan, JIA GuoLiang, GUO WenYi, HE Zheng, ZHANG Qing, ZHENG XiaoRong

    Department of Cardiovasology, Polyclinic, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To study the effects of bisoprolol on plasma calcitonin gene related peptide (CGRP), endothelin (ET)1 levels and heart functions in patients with chronic heart failure.METHODS: Sixtyeight patients with chronic heart failure were divided into two groups: the bisoprolol group and the control group. Blood samples were drawn from median cubital veins of all these patients at the beginning of the study and followup after the 7month. The plasma concentration of ET1 and CGRP were detected by radioimmunoassay, and the left ventricular ejection fraction (EF%) were recorded to evaluate the effects of bisoprolol.RESULTS: At the end of 7month follow up, the plasma concentrations of ET1 and CGRP in bisoprolol group decreased significantly compared with those at the beginning of the study (P<0.01) and it was also true compared with those of the control group (P<0.01).The values of EF% were higher in both groups after 7month followup, and the values of EF% was significantly higher in the bisoprolol group than those in the control group (all P<0.01). CONCLUSION: Bisoprolol added to other routine drugs can decrease the levels of the plasma CGRP and ET1 and improve the heart functions of patients with heart failure. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/02/19/87/25/28.htm

您现在查看是摘要页，全文长 11297 字符。