皮肤移植__(期刊论文)

口服供者脾细胞诱导成年大鼠皮肤移植物存活期延长

http://www.100md.com 《第四军医大学学报》 2003年第8期

皮肤移植,,口服抗原；皮肤移植；淋巴细胞培养试验；超敏反应，迟发型,0引言,1材料和方法,2结果,3讨论,【参考文献】

     (第四军医大学西京医院泌尿外科，陕西西安 710033，解放军309医院泌尿外科，北京 100091)

    Prolongation of survival of skin allografts in adult rat by feeding of donor spleen cells

    TONG JianQiu,WANG He,SHEN RuiXiong,SHI BingYi,MO ChunBai,ZHOU WenQiang

    Department of Urology, Xijing Hospital,Fourth Military Medical University, Xian 710033,China, Department of Urology, 309 Hospital of Chinese PLA,Beijing 100091, China

    【Abstract】 AIM: To investigate the survival time of skin allograft in recipient rat by orally feeding donors spleen cells and to study the mechanism of oral tolerance. METHODS：The inbred SD rats were chosen as skin donors and inbred Wistar rats as recipients, and heterotopic skin transplantations were performed. The 20 recipients were classified into 2 groups randomly. In group A (control group) heterotopic skin transplantations were performed and in group B (feeding group) heterotopic skin transplantations were performed following a 7day feeding of 5×107 (daily) donor splenocytes by means of gastric intubation. The mixed lymphocyte culture in vitro and delayedtype hypersensitivity(DTH) response in vivo were examined and the survival time of skin allograft was observed. RESULTS： Lymphocytes from Wistar rats that were prefed with allogenetic SD rats splenocytes exhibited a significant reduction of mixed lymphocyte response in vitro and delayedtype hypersensitivity response in vivo, compared with the unfed controls. While the unfed controls rejected the skin allografts within (4.9±0.1) days, the prefeds skin allograft survival time was (158±13) days.(P<0.01, n = 10). CONCLUSION： Orally administered alloantigen can downregulate the immune response to histocompatibility antigens, thus prolonging the survival time of skin allograft. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/02/19/87/25/34.htm

您现在查看是摘要页，全文长 13170 字符。