Experimental study of effects of XueSaiTong Injection on obstructive jaundice caused renal injury in rabbits

    SONG Shaoª²Li, ZHOU Bin, CHENG Yanª²Bin, WANG Hongª²Liang, TANG Xiaoª²Qin

    1Department of Nuclear Medicine, First Hospital, Lanzhou Medical College, Lanzhou 730000, China, 2Cadet Healthª²care Hospital of Gansu Province, 3Department of Anatomy, Lanzhou Medical College, 4Pin¡¯an Insurance Company Lanzhou Branch

    ¡¾Abstract¡¿ AIM: To study the protective effects of XueSaiTong Injection on the renal injury caused by obstructive jaundice (OJ) in rabbits. METHODS: Fortyª²eight rabbits were first randomly divided into two groups: the group of OJ (group A, 24 rabbits) and the group of OJ treated with XueSaiTong Injection (group B, 24 rabbits). Then each group was further subdivided into four subgroups and all the rabbits used in this study were raised under the same condition. Auto biochemical analysis equipment was used to examine the Tª²BIL, Cr and BUN in serum at different times and immunohistochemistry was used to determine the expressions of Bax and Bclª²2 on renal. RESULTS: Expressions of Bclª²2 and Bax on the renal tissues were observed following OJ. The expression of Bax reached the peak value at the 9th d and the highest expression of Bclª²2 was observed at the 21st d. The apoptosis index (AI) increased with the increase of Bax expression but decreased with Bclª²2 strong expression. A lower expression of Bax and a higher expression of Bclª²2 were found in group B compared with those of group A. The AI value was also lower in group B than that in group A. CONCLUSION: XueSaiTong Injection has some protective effects on the renal injury caused by OJ, for XueSaiTong Injection may upª²regulate the expression of Bclª²2 and downª²regulate the expression of Bax in renal tissues. ......