高效液相色谱__(期刊论文)

Beagle犬体内MN9202的测定及其代谢动力学

http://www.100md.com 《第四军医大学学报》 2004年第19期

高效液相色谱,,MN9202；药物代谢动力学；高效液相色谱；半衰期；正交试验,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Determination and pharmacokinetics of MN9202 in Beagle dogs

    YANG ZhiFu, ZHOU SiYuan, YANG TieHong, MEI QiBing, LIU Li

    Department of Pharmacology, School of Basic Medicine, Fourth Military Medical University, Xi’an 710033, China

    【Abstract】 AIM: To set up a sensitive and rapid high performance liquid chromatography (HPLC) method to determine MN9202 and to study its pharmacokinetics in Beagle dogs. METHODS: The mobile phase and extraction methods were optimized by the orthogonal experimental design. MN9202 was intravenously administered to the Beagle dogs at the dose of 0.335 mg/kg and MN9202 in plasma was detected by HPLC. The pharmacokinetic parameters were calculated by 3P97 software. RESULTS: Under the selected HPLC conditions, the MN9202 was clearly separated from interference and the retention time of MN9202 was less than 14 min. When MN9202 was intravenously administered, the plasma concentrationtime curve was fit to twocompartment model. T1/2β was (200±32) min. and AUC was (32 147±9544)μg·min/L. CONCLUSION: The analytical method we set up is simple, sensitive and accurate, and it can be applied to determine the MN9202 in the plasma of Beagle dogs. The speed of elimination of MN9202 is high in Beagle dogs. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/02/19/87/25/71.htm

您现在查看是摘要页，全文长 7668 字符。