癌症疫苗_____小鼠；癌，肝细胞；B7.1；癌症疫苗

小鼠肝癌细胞系Hepa16 B7.1瘤苗抗肿瘤免疫的实验研究

http://www.100md.com 《第四军医大学学报》 2003年第6期

癌症疫苗,,小鼠；癌，肝细胞；B7.1；癌症疫苗,小鼠肝癌细胞系Hepa16B7.1瘤苗抗肿瘤免疫的实验研究,0引言,1材料和方法,2结果,3讨论,【参考文献】

     (第四军医大学基础部病理学教研室，陕西西安 710033)

    Experimental study of antitumor immunity induced by tumor cells vaccine of murine hepatocellular carcinoma cell line (Hepa16)

    YANG XinWei, SUI YanFang, LI ZengShan, QU Ping, WU Wen, YE Jing, DONG HaiLong, ZHANG XiuMin

    Department of Pathology, Faculty of Preclinical Medicine,Fourth Military Medical University, Xian 710033， China

    【Abstact】AIM: To study the efficacy of antitumor immunity both in vivo and in vitro with B7.1 gene induced into murine hepa16 hepatocellular carcinoma cells. METHODS : pLXSN B7.1 was transfected into packaging cell line PA317 by liposome induction and high titer positive clone was acquired by G418. The expression of B7.1 molecules was detected by FACS. Antitumor immunity in vivo and in vitro was observed following transfection of B7.1 gene into Hepa 16 cell line, which acted as a tumor vaccine. RESULTS: B7.1 molecules were highly expressed in Hepa 16/B7.1, with decreased tumor induction and protective immunity effect. CONCLUSION: Hepa16 hepatocellular carcinoma cells transfected with B7.1 genes as a kind of tumor vaccine can effectively trigger the host antitumor immunity. ......

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