再灌注损伤_____核因子κB；神经元；再灌注损伤

核因子κB在原代神经细胞缺血再灌注的表达

http://www.100md.com 《第四军医大学学报》 2003年第7期

再灌注损伤,,核因子κB；神经元；再灌注损伤,0引言,1材料和方法,2结果,3讨论,【参考文献】

     (第四军医大学西京医院神经内科,陕西西安 710033)

    Expression of nuclear transcription factor NFκB in primary cultured neurons following ischemiareperfusion injury

    TIAN Ye, WAN Qi, LIU YongHong, LI Li

    Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To explore the expression of nuclear factor NFκB in primary cultured mouse fetus neurons. METHODS: The neurons primarily cultured in vitro after ischemialike reperfusion, and the expression of NFκB was assayed by immunofluorescence and flow cytometry. RESULTS: Immunofluorescence results showed that the expression of NFκB increased and moved from cytoplasm to nuclear. Flow cytometry results showed that the expression of NFκB was 1.28% (before ischemiareperfusion) and 38.72% (after ischemiareperfusion). CONCLUSION: NFκB exits in neural cells and after ischemiareperfusion injury it will be activated, move from cytoplasma to nuclei and play a regulatory role of gene transcription. ......

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