Protective effects of multiple antioxidants on heart injury of rats with liver embeddedª²tumor induced by adriamycin

    HE Wei£¬ QIN Xuª²Jun£¬ HAI Chunª²Xu£¬ LIANG Xin£¬ ZHAO Kangª²Tao£¬ ZHANG Xiaoª²Di£¬ CHEN Hongª²Li£¬ LIU Rui

    Department of Toxicology, School of Preventive Medicine, Fourth Military Medical University, Xi¡¯an 710033, China

    ¡¾Abstract¡¿ AIM: To investigate the oxidative heart injury of rats with liver embeddedª²tumor induced by adriamycin and the protective effects of multiple antioxidants on it. METHODS: The tumor cells (Walkerª²256) were injected into the rats to create the entity tumors. When the entity tumors were removed from the rats, they were cut into small pieces and embedded into the rats¡¯ livers. The rats with entity tumor were randomly divided into three groups: Tumor group, chemotherapy group and protective group. The rats without liver embeddedª²tumor were selected as negative controls. The protective group was given compound antioxidants by gavage daily and the tumor group and chemotherapy group were given adriamycin by intraperitoneal injection at the dosage of 2 mg/kg body weight every two days. All the rats were killed at the end of eighth week. After their hearts were collected ......