脑损伤_____高压氧;_脑损伤;_脑;

高压氧对弥漫性脑损伤大鼠组织病理学的影响

http://www.100md.com 《第四军医大学学报》 2003年第8期

脑损伤,,高压氧;,脑损伤;,脑;,病理学；大鼠,0引言,1材料和方法,2结果,3讨论,【参考文献】

     (第四军医大学唐都医院急诊科，陕西西安 710038，西安高新医院检验科，陕西西安 720075，第四军医大学航空航天医学系高压氧治疗中心，陕西西安710033)

    Effect of hyperbaric oxygen on diffuse injured rats brain histopathology

    WANG BoLiang, CAO YiZhan, JING Xing,ZHONG YueXia, LI JinSheng,LU Jiang, HE BaoJian, Fu GuoQiang

    Department of Emergency Medicine, Tangdu Hospital, Fourth Military Medical University, Xian 710038, China, Department of Clinical Laboratories, Xian Gaoxin Hospital, Xian 720075, China, Center of Hyperbaric Oxygen Treatment, Faculty of Aerospace Medicine, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To investigate the effect of hyperbaric oxygen on diffuse injured rats brain histopathology. METHODS: We produced headinjured animal model by an weightdropt device designed by Marmarou, the effects of 02 MPa hyperbaric oxygen on brain injury were observed at different time after trauma(6 h, 1 d, 2 d, 3 d, 1 wk, 2 wk and 3 wk). The expression of neurofilament(NF)was observed after trauma using immunohistochemistry methods. The content of water in the rat brain tissue was measured by dried/wet weight method. RESULTS: After trauma, diffuse neuronal degeneration and necrosis were seen and brain water content increased. Axonal rupture was observed by NF staining. But the number of damaged neurons and the brain water content decreased significantly in the HBO group (P<005). CONCLUSION: These results show that diffuse degeneration, necrosis, edema and axonal injury occur after trauma and HBO treatment may decrease the damaged neurons and alleviate brain edema. ......

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