多囊卵巢综合征_____多囊卵巢综合征；

二甲双胍与克罗米芬联合治疗难治性多囊卵巢综合征

http://www.100md.com 《第四军医大学学报》 2003年第6期

多囊卵巢综合征,,多囊卵巢综合征；,二甲双胍；,不育，女(雌)性,0引言,1对象和方法,2结果,3讨论,【参考文献】

     (第四军医大学西京医院妇产科，陕西西安 710033)

    Treatment of clomipheneresistant polycystic ovary syndrome with metformin and clomiphene citrate

    ZHAO HaiBo, LU XiaoJuan, REN JuXia, LI AiLi

    Department of Obstetrics & Gynecology, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM： To observe the treatment effects of metformin combined with clomiphene citrate (CC) on CCresistant polycystic ovary syndrome (PCOS). METHODS： The patients with CCresistant POCS were first given metformin for 2 months, then given metformin and CC for 3 cycles, during which time the patients’ sexual hormone changes, ovarian follicular development, endometrial thickness and their patterns, and pregnancy rate were observed and the results were compared with those of simple CC cycles. RESULTS： There were 19 cases of CCresistant PCOS among the 87 PCOPS patients. After the treatment of metformin for 2 months the patients’ LH and T levels declined and E2 level rose (P<0.01). In the following 3 treatment cycles of metformin and CC, 9-14 mm of thickness and A pattern of endometrium increased, ovulation rate was 35% and pregnancy rate was 32%. These changes were very significant compared with those of simple CC cycles (P<0.01). CONCLUSION： Metformin combined with CC is an effective treatment for CCresistant PCOS. ......

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