吸氧预处理诱导的大鼠脑内Fos表达
氧疗,,氧疗；预处理；基因，,fos；大鼠；脑,0引言,1材料和方法,2结果,3讨论,【参考文献】
(第四军医大学： 西京医院麻醉科， 神经科学研究所，陕西 西安 710033)Fos expression in rat brain induced by preconditioning with pure oxygen inhalation
ZHANG XiJing, XIONG LiZe, WANG Xi, HU WenNeng
Department of Anesthesiology, Xijing Hospital, Institute of Neuroscience, Fourth Military Medical University, Xian 710033, China
【Abstract】 AIM: To investigate whether oncogene cfos is involved in the regulation of the brain ischemic tolerance induced by oxygeninhaling preconditioning. METHODS: SD rats were randomly divided into 2 groups: oxygeninhaling preconditioning group and control group (n=6 each). The rats in oxygeninhaling preconditioning group inhaled Pure oxyen for 24 h, while the control animals inhaled 210 mL·L-1 Pure oxgen for 24 h. 24 h after the treatment, all the rats were perfused transcardially and the brains were moved out. The Fos expression in rat brain was detected by using ABC immunohistochemistry method and the difference between the two groups was studied. RESULTS: There was a widespread expression of Foslike reactivity production and the distribution patterns in the two groups were similar. However, the Fos expression increased in oxygeninhaling preconditioning rats in the following brain areas: solitary tract nucleus, area postrema, lateral parabranchial nucleus, caudal part of spinal nucleus of 5th nerve, ventrol tegmental nucleus, periaqueductal nucleus, supramammillary nucleus, supraoptic nucleus, hippocampus, subiculum, posterolateral cortical amygdaloid nucleus, anterior cortical amygdaloid nucleus, lateral septal nucleus, bed nucleus of stria terminalis, globus pallidus, Calleja island, occipital cortex, retrosplenial cortex, parietal cortex, forelimb and hindlimb area of cortex, and frontal cortex. CONCLUSION: Some nuclei can be activated by oxygeninhaling preconditioning. Oncogene cfos is involved in the regulation of the brain ischemic tolerance induced by oxygeninhaling preconditioning. ......
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