氟伐他汀_____氟伐他汀;气道；肌，平滑;

氟伐他汀对大鼠气道平滑肌增生的影响

http://www.100md.com 《第四军医大学学报》 2003年第6期

氟伐他汀,,氟伐他汀;气道；肌，平滑;,增生；哮喘,0引言,1材料和方法,2结果,3讨论,【参考文献】

     (第四军医大学：西京医院呼吸内科，全军神经科学研究所，陕西西安 710033)

    Effects of fluvastatin on the proliferation of ASMC in rats

    LI Yi, QI HaoWen, LIU YingGe, CHEN BingYao

    Department of Respiratory, Xijing Hospital,2Institute of Neuroscience of Chinese PLA, Fourth Military Medical University, Xian 710033, China

    【Abstract】AIM： To study the effects of fluvastatin, a new synthetic inhibitor of 3-hydrox-3-methylglutaryl coenzyme A (HMG-CoA) reductase, on the proliferation of airway smooth muscle cell (ASMC) from rats. METHODS： MTT and cell growth counts were used to analyze the effects of fluvastatin on the proliferation of ASMC. RESULTS： Fluvastatin inhibited the proliferation of ASMC stimulated by fetal calf serum or histamine. The inhibitory rate of the proliferation of ASMC was above 20% or 100% when the concentrations of fluvastatin were 10-5 mol· L-1 or 10-4 mol·L-1 and there was a concentration-dependent decrease in the proliferation of rat ASMC. CONCLUSION： Fluvastatin can inhibit ASMC proliferation either stimulated by fetal calf serum or histamine.

    【Keywords】 fluvastatin; airway;muscle ......

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