结肠直肠肿瘤_____结肠直肠肿瘤；基质溶素；β连环素；

β连环素和基质溶素在大肠癌发生发展中的作用

http://www.100md.com 《第四军医大学学报》 2004年第18期

结肠直肠肿瘤,,结肠直肠肿瘤；基质溶素；β连环素；,肿瘤侵润；肿瘤转移,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Effect of βcatenin and matrilysin in progression of colorectal cancer

    ZHAO Yong, ZHANG BiCheng, GAO JianFei, LI Xin, DU GuangZu

    Department of Oncology, Wuhan General Hospital, Guangzhou Military Command, PLA, Wuhan 430070, China

    【Abstract】 AIM: To investigate the correlation of βcatenin and matrilysin expression with the progression of colorectal carcinoma. METHODS: High sensitive SP immunohistochemical method was used to detect the proteins of βcatenin and matrilysin in clinical specimens. RESULTS: In some cases of adenoma, early colorectal cancer, advanced colorectal cancer, abnormal βcatenin expression with loss of membranous immunoreactivity or cytoplasmic or nuclear staining was observed and the cytoplasm expression of matrilysin was demonstrated. The abnormal βcatenin expression decreased from normal muscosa, aberrant crypt foci, adenoma, earlycolorectalcancertoadvancedcolorectal cancer (P<0.05, respectively), and the positive expression of matrlysin gradually increased. The membranous expression rates of βcatenin gradually decreased with tumor cell dedifferentiation (P<0.05). Cytoplasmic or nuclear expression of βcatenin or matrilysin expression was not significantly associated with histological differentiation (P>0.05). The abnormal βcatenin expression and matrilysin positive rate in early colorectal cancer were significantly associated with the depth of invasion and metastasis (P<0.05, respectively). In early colorectal cancer, the matrilysin expression was not correlated with the membranous expression of βcatenin (P>0.05), while it was positively correlation with the cytoplasmic or nuclear expression of βcatenin (P<0.05, respectively). CONCLUSION: βcatenin and matrilysin may play an important role in the carcinogenesis, infiltration and metastasis of colorectal cancer. ......

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