Study of TORCH infection in pregnant women and fetal abnormalities

    LIU Jin, GU Xiaoª²Hui, YE Guoª²Ling, ZHAO Xiaoª²Lan, ZHANG Lei,WU Jinª²Fang, CAI Xiaoª²Ning, LIU Qi

    1Laboratory of Prepotency & Genetics, Department of Obstetrics & Gynecology, Second Hospital, 2Department of Microbiology, Medicine College, Xi¬ðan Jiaotong University, Xi¬ðan 710004, China

    ¡¾Abstract¡¿ AIM: To study the relationship between TORCH infection in pregnant women and fetal abnormalities. METHODS: Enzyme linked immonosorbent assay (ELISA) was applied to detect TORCH IgM in the serum of 1000 pregnant women and TORCH DNA in the blood of pregnant women with TORCH IgM positive and abnormal pregnancy history was detected by polymerase chain reaction (PCR). RESULTS: The pregnant women TORCH IgM positive rate was 11.60%, TOX, RV, HCMV, HSVIgM positive rate was respectively 3.60%, 2.50%, 3.40% and 2.10%.The rate of TORCH intrauterine was 33.33% and that of TOX, RV, HCMV, HSV was respectively 43.33%, 26.32%, 34.62%, and 18.18%. The TORCH IgM positive rate of pregnant women with flu symptoms (21.51%) was significantly higher than that (9.34%) of women without flu symptoms (P<0.01). The TORCH IgM positive rate of pregnant women with fetal abnormality history (42.10%), or with abnormal pregnancy history (25.40%) was also significant higher than that (8.13%) of women with normal pregnancy(P<0.01). The rate of fetal abnormality (12.37%) in TORCH DNA positive group was significantly higher than that (1.07%) of negative group (P<0.01). CONCLUSION: TORCH infection in pregnant women is a factor causing fatal abortion and abnormalities. ......