地黄的形态结构与化学成分研究进展.PDF
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[ 1 ] Shah V P, M idha K K, D ighe S, et al1 A nalyt ical methods
validat ion: bioavailability, bioequivalence, and pharma2
cok inet ic studies [J ]1 J P harm S ci, 1992, 81: 301
[ 2 ] L i X Z, Chen X, Yang Y J , et al1 Pharmacok inet ic study of
baicalin in rabbits w ith inf lammato ry brain edema [J ]1 Ch in
P harm J (中国药学杂志) , 1999, 34 (2) : 10721091
[ 3 ] Chang Q , Zhu M , Zuo Z H, et al1 H igh2 perfo rmance liquid
ch romatograph ic methods fo r simultaneous determ inat ion of
haw tho rm act ive components in rat p lasma [J ]1 J Ch ro2
m atog r (B ) , 2001, 760 (2) : 22722351
[ 4 ] N ielsen S E, D ragsted L O 1 Co lumn2sw itch ing h igh2 perfo r2
mance liquid ch romatograph ic assay fo r the determ inat ion of
quercet in in human urine w ith ult ravio let abso rbance detec2
t ion [J ]1 J Ch rom atog r (B ) , 1998, 707 (2) : 812891
[ 5 ] Erlund I, A lf than G, Siren H, et al1 V alidated method fo r
the quant itat ion of quercet in f rom human p lasma using h igh2
perfo rmance liquid ch romatography w ith elect rochem ical de2
tect ion [J ]1 J Ch rom atog r (B ) , 1999, 727 (2) : 17921891
[ 6 ] Du Y, Chen X Y, Yang H Y, et al1 Determ inat ion of wogo2
nin in rat p lasma by liquid ch romatography2tandem mass
spect romet ry [J ]1 A cta P harm S in (药学学报) , 2002, 37
(5) : 36223661
[ 7 ] Kienzler J L , Sallin D, Sch iff lers M H, et al1 Pharma2
cok inet ics of mono23′ 2 and mono24′ 2 O 2(beta2 hydroxyethyl) 2
ruto side derivat ives, af ter single do ses of V eno rutonpowder
in healthy vo lunteers [J ]1 E u r J C l in P harm acol, 2002, 58
(6) : 39524021
[ 8 ] Crepy V , Mo rand C, Besson C, et al1Q uercet in, but no t its
glyco sides, is abso rbed f rom the rat stomach [J ]1 J A g ric
Food Chem , 2002, 50 (3) : 61826211
[ 9 ] Mo rand C, M anach C, Crespy V , et al1Q uercet in 32 O 2 beta2
gluco side is bet ter abso rbed than o ther quercet in fo rm s and is
no t p resent in rat p lasma [J ]1 F ree R ad ic R es, 2000, 33 (5) :
66726761
[ 10 ] Ho llman P C, Bijsman M N , V an Gameren Y, et al1 The
sugar mo iety is a majo r determ inant of the abso rp t ion of die2
tary f lavono id glyco sides in man [J ]1 F ree R ad ic R es, 1999,31 (6) : 56925731
[ 11 ] Zou J M , M eng J , Yan Z H, et al1 Pharmacok inet ic studies
of icariin in Ch inese fo rmulated medicine [J ]1 Ch in T rad it
H erb D rug s (中草药) , 2002, 33 (1) : 552581
[ 12 ] Zhou Y J , Che Q M , Xu S X, et al1M etabo lites of baicalein
in human urine [J ]1 P harm az ie, 2000, 55 (8) : 62626271
[ 13 ] Che Q M , Huang X L , L i YM , et al1 Studies on metabo lites
of baicalin in human urine [J ]1 Ch ina J Ch inM aterM ed (中
国中药杂志) , 2000, 26 (11) : 76827691
[ 14 ] L aiM Y, H siu S L , T sai S Y, et al1 Comparison of metabo2
lic pharmacok inet ics of baicalin and baicalein in rats [J ]1 J
P harm P harm acol, 2003, 55 (2) : 20522091
[ 15 ] Q iu F, Chen Y J , Kano Y H, et al1M etabo lism of o rally ad2
m inistered icariin in rats [J ]1 A cta P harm S in (药学学报) ,1999, 34 (3) : 22222261
[ 16 ] L ai M Y, H siu S L , Chen C C, et al1 U rinary pharma2
cok inet ics of baicalein, wogonin and their glyco sides af ter
o ral adm inist rat ion of R ad ix S cu tel lariae in humans [J ]1 B iol
P harm B u l l, 2003, 26 (1) : 792831
[ 17 ] He X, Sh i C W , L i X, et al1 The pharmacok inet ic study of
baicaline in Shuanghuanglian Powder Inject ion [J ]1 Ch in
N ew D rug s J (中国新药杂志) , 1998, 7 (7) : 14621481
[ 18 ] Hou Y C, Chao P D, Ho H J , et al1 P rofound difference in
pharmacok inet ics between mo rin and its isomer quercet in in
rats [J ]1 J P harm P harm acol, 2003, 55 (2) : 19922031
地黄的形态结构与化学成分研究进展
王太霞1, 2
, 李景原1
, 胡正海1X
(11西北大学生命科学学院, 陕西 西安 710069; 21河南师范大学生命科学学院, 河南 新乡 453002)
摘 要: 地黄为传统的大宗中药材, 国内外对地黄已进行了多方面的研究, 现对近年来地黄的形态结构及主要药用
成分的研究进行综述, 为地黄的进一步研究提供理论依据 ......
validat ion: bioavailability, bioequivalence, and pharma2
cok inet ic studies [J ]1 J P harm S ci, 1992, 81: 301
[ 2 ] L i X Z, Chen X, Yang Y J , et al1 Pharmacok inet ic study of
baicalin in rabbits w ith inf lammato ry brain edema [J ]1 Ch in
P harm J (中国药学杂志) , 1999, 34 (2) : 10721091
[ 3 ] Chang Q , Zhu M , Zuo Z H, et al1 H igh2 perfo rmance liquid
ch romatograph ic methods fo r simultaneous determ inat ion of
haw tho rm act ive components in rat p lasma [J ]1 J Ch ro2
m atog r (B ) , 2001, 760 (2) : 22722351
[ 4 ] N ielsen S E, D ragsted L O 1 Co lumn2sw itch ing h igh2 perfo r2
mance liquid ch romatograph ic assay fo r the determ inat ion of
quercet in in human urine w ith ult ravio let abso rbance detec2
t ion [J ]1 J Ch rom atog r (B ) , 1998, 707 (2) : 812891
[ 5 ] Erlund I, A lf than G, Siren H, et al1 V alidated method fo r
the quant itat ion of quercet in f rom human p lasma using h igh2
perfo rmance liquid ch romatography w ith elect rochem ical de2
tect ion [J ]1 J Ch rom atog r (B ) , 1999, 727 (2) : 17921891
[ 6 ] Du Y, Chen X Y, Yang H Y, et al1 Determ inat ion of wogo2
nin in rat p lasma by liquid ch romatography2tandem mass
spect romet ry [J ]1 A cta P harm S in (药学学报) , 2002, 37
(5) : 36223661
[ 7 ] Kienzler J L , Sallin D, Sch iff lers M H, et al1 Pharma2
cok inet ics of mono23′ 2 and mono24′ 2 O 2(beta2 hydroxyethyl) 2
ruto side derivat ives, af ter single do ses of V eno rutonpowder
in healthy vo lunteers [J ]1 E u r J C l in P harm acol, 2002, 58
(6) : 39524021
[ 8 ] Crepy V , Mo rand C, Besson C, et al1Q uercet in, but no t its
glyco sides, is abso rbed f rom the rat stomach [J ]1 J A g ric
Food Chem , 2002, 50 (3) : 61826211
[ 9 ] Mo rand C, M anach C, Crespy V , et al1Q uercet in 32 O 2 beta2
gluco side is bet ter abso rbed than o ther quercet in fo rm s and is
no t p resent in rat p lasma [J ]1 F ree R ad ic R es, 2000, 33 (5) :
66726761
[ 10 ] Ho llman P C, Bijsman M N , V an Gameren Y, et al1 The
sugar mo iety is a majo r determ inant of the abso rp t ion of die2
tary f lavono id glyco sides in man [J ]1 F ree R ad ic R es, 1999,31 (6) : 56925731
[ 11 ] Zou J M , M eng J , Yan Z H, et al1 Pharmacok inet ic studies
of icariin in Ch inese fo rmulated medicine [J ]1 Ch in T rad it
H erb D rug s (中草药) , 2002, 33 (1) : 552581
[ 12 ] Zhou Y J , Che Q M , Xu S X, et al1M etabo lites of baicalein
in human urine [J ]1 P harm az ie, 2000, 55 (8) : 62626271
[ 13 ] Che Q M , Huang X L , L i YM , et al1 Studies on metabo lites
of baicalin in human urine [J ]1 Ch ina J Ch inM aterM ed (中
国中药杂志) , 2000, 26 (11) : 76827691
[ 14 ] L aiM Y, H siu S L , T sai S Y, et al1 Comparison of metabo2
lic pharmacok inet ics of baicalin and baicalein in rats [J ]1 J
P harm P harm acol, 2003, 55 (2) : 20522091
[ 15 ] Q iu F, Chen Y J , Kano Y H, et al1M etabo lism of o rally ad2
m inistered icariin in rats [J ]1 A cta P harm S in (药学学报) ,1999, 34 (3) : 22222261
[ 16 ] L ai M Y, H siu S L , Chen C C, et al1 U rinary pharma2
cok inet ics of baicalein, wogonin and their glyco sides af ter
o ral adm inist rat ion of R ad ix S cu tel lariae in humans [J ]1 B iol
P harm B u l l, 2003, 26 (1) : 792831
[ 17 ] He X, Sh i C W , L i X, et al1 The pharmacok inet ic study of
baicaline in Shuanghuanglian Powder Inject ion [J ]1 Ch in
N ew D rug s J (中国新药杂志) , 1998, 7 (7) : 14621481
[ 18 ] Hou Y C, Chao P D, Ho H J , et al1 P rofound difference in
pharmacok inet ics between mo rin and its isomer quercet in in
rats [J ]1 J P harm P harm acol, 2003, 55 (2) : 19922031
地黄的形态结构与化学成分研究进展
王太霞1, 2
, 李景原1
, 胡正海1X
(11西北大学生命科学学院, 陕西 西安 710069; 21河南师范大学生命科学学院, 河南 新乡 453002)
摘 要: 地黄为传统的大宗中药材, 国内外对地黄已进行了多方面的研究, 现对近年来地黄的形态结构及主要药用
成分的研究进行综述, 为地黄的进一步研究提供理论依据 ......
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