溃疡性结肠炎结肠黏膜修复中HGF, c-Met, EGFR的作用
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陈 凡, 林 琳, 张红杰, 叶晓霞, 赵伟志,
溃疡性结肠炎;肝细胞生长因子;c-Met;表皮生长因子受体;增殖细胞核抗原,溃疡性结肠炎结肠黏膜修复中HGF,c-Met,EGFR的作用,陈凡,林琳,张红杰,叶晓霞,赵伟志,王涛,杨希宁,陈凡
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陈凡, 林琳, 张红杰, 南京医科大学第一附属医院消化科 江苏省南京市 210029
叶晓霞, 赵伟志, 马钢医院病理科 安徽省马鞍山市 243000
王涛, 杨希宁, 马钢医院消化科 安徽省马鞍山市 243000
陈凡, 1986年安徽医科大学学士, 2001年南京医科大学在职硕士生, 副主任医师, 主要从事炎症性肠病临床和研究工作
江苏省自然科学基金资助项目, No.BK2004158
江苏省135工程重点人才基金资助项目, No.苏卫科教[2003]19号
通讯作者: 林琳, 210029, 江苏省南京市广州路300号, 南京医科大学第一附属医院消化科. lin9100@yahoo.com.cn
电话: 025-83718836-6920 传真: 025-83673363
收稿日期: 2005-12-30 接受日期: 2006-01-03
Roles of hepatocyte growth factor, c-Met and epidermal growth factor receptor in repair of colonic mucosa from patients with ulcerative colitis
Fan Chen, Lin Lin, Hong-Jie Zhang, Xiao-Xia Ye, Wei-Zhi Zhao, Tao Wang, Xi-Ning Yang
Fan Chen, Lin Lin, Hong-Jie Zhang, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Xiao-Xia Ye, Wei-Zhi Zhao, Department of Pathology, Magang Hospital, Ma’anshan 243000, Anhui Province, China
Tao Wang, Xi-Ning Yang, Department of Gastroenterology, Magang Hospital, Ma’anshan 243000, Anhui Province, China
Supported by the Natural Science Foundation of Jiangsu Province, No. BK2004158, and the Fund from “135 Project” for the Key Talents of Health and Science Education Department of Jiangsu Province, No. [2003]19
Correspondence to: Dr. Lin Lin, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. lin9100@yahoo.com.cn
Received: 2005-12-30 Accepted: 2006-01-03
Abstract
AIM: To investigate the expression of hepatocyte growth factor (HGF), c-Met and epidermal growth factor receptor (EGFR) in colonic mucosa from patients with active or inactive ulcerative colitis and their clinical significances.
METHODS: Forty-two patients with ulcerative colitis were divided into 2 groups (active: n = 25; inactive: n = 17) according to the modifi-ed Williams Disease Activity Index (DAI) ......
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