利用组织芯片技术研究COX-2在胃癌中的表达及其与血管生成的关系
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吕晓君, 毛晓韵, 李锦毅, 韩琤波, 吴东瑛,
胃癌;环氧合酶;组织芯片;微血管密度,吕晓君,毛晓韵,韩琤波,吴东瑛,张淑敏,辛彦,李锦毅,吕晓君,通讯作者:,Studyofc
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吕晓君, 毛晓韵, 韩琤波, 吴东瑛, 张淑敏, 辛彦, 中国医科大学附属第一医院肿瘤研究所第四研究室 辽宁省沈阳市 110001
李锦毅, 武警总医院中心实验室 北京市海淀区 100039
吕晓君, 女, 1965-12-03生, 辽宁省辽阳市人, 汉族, 2000年中国医科大学肿瘤学硕士, 副主任医师, 主要从事肿瘤临床及基础研究.
国家自然基金资助项目, No. 30371607
通讯作者: 辛彦, 110001, 辽宁省沈阳市和平区南京北街155号, 中国医科大学附属第一医院肿瘤研究所第四研究室.
电话: 024-23256666-6351 传真: 024-22703576
收稿日期: 2005-10-11 接受日期: 2005-11-04
Study of cyclooxygenase-2 expression in gastric cancer and its relationship with angiogenesis by tissue microarray
Xiao-Jun Lv, Xiao-Yun Mao, Jin-Yi Li, Cheng-Bo Han, Dong-Ying Wu, Shu-Min Zhang, Yan Xin
Xiao-Jun Lv, Xiao-Yun Mao, Cheng-Bo Han, Dong-Ying Wu, Shu-Min Zhang, Yan Xin, the Fourth Laboratory of Cancer Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Jin-Yi Li, the Central Laboratory, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China
Supported by the National Natural Science Foundation of China, No. 30371607
Correspondence to: Professor Yan Xin, the Fourth Laboratory of Cancer Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Received: 2005-10-11 Accepted: 2005-11-04
Abstract
AIM: To explore the expression and clinical-pathological significance of cyclooxygenase-2 (COX-2) as well as its relations with the angioge-nesis in the carcinogenesis and metastasis of gastric cancer.
METHODS: The expression of COX-2 was detected by EnVision immunohistochemical method in tissue microarray prepared from gastric cancer patients. The microvessel density (MVD) was calculated after CD34 staining for microvessel endothelium. Their correlations were analyzed.
RESULTS: The expression of COX-2 in gastric cancer was significantly higher than that in normal controls (P = 0.001). The over-expression of COX-2 in gastric cancer was positively related to the metastasis and the depth of invasion (P = 0 ......
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