间隙连接蛋白32, 43的表达对胃癌侵袭转移潜能的影响
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吴 瑾, 王翠华, 周红凤, 刘 丹, 王 雯,
连接蛋白;间隙连接通讯;胃癌;转移潜能,间隙连接蛋白32,43的表达对胃癌侵袭转移潜能的影响,吴瑾,王翠华,周红凤,刘丹,王雯,张波,隋广杰,吴瑾,通讯作者:,Relationsofconnexi
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吴瑾, 王翠华, 周红凤, 刘丹, 王雯, 张波, 隋广杰, 哈尔滨医科大学附属肿瘤医院 黑龙江省哈尔滨市 150040
吴瑾, 女, 1963-12-13生, 黑龙江省哈尔滨人, 汉族, 哈尔滨医科大学肿瘤学在读博士, 教授, 硕士生导师, 主要从事恶性肿瘤的发生、发展及转移方面的研究.
通讯作者: 吴瑾, 150040, 哈尔滨市南岗区哈平路150号, 哈尔滨医科大学附属肿瘤医院内科. xianlliu@public.hr.hl
电话: 0451-86298730
收稿日期: 2005-09-28 接受日期: 2005-09-30
Relations of connexin 32 and 43 expression with metastatic potential of gastric cancer
Jin Wu, Cui-Hua Wang, Hong-Feng Zhou, Dan Liu, Wen Wang, Bo Zhang, Guang-Jie Sui
Jin Wu, Cui-Hua Wang, Hong-Feng Zhou, Dan Liu, Wen Wang, Bo Zhang, Guang-Jie Sui, the Affiliated Tumor Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China
Correspondence to: Wu Jin, Department of Internal Medicine, the Affiliated Tumor Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China. xianlliu@public.hr.hl
Received: 2005-09-28 Accepted: 2005-09-30
Abstract
AIM: To investigate the relationship between the expression of connexin (Cx) 32 and 43 and metastatic potential of gastric cancer.
METHODS: Indirect immunofluorescent method and SP immunohistochemistry were used to examine the expression of Cx32 and Cx43 in gastric tissues from normal controls and patients with carcinoma of variously differentiated grades as well as in the gastric cancer cells of variously differentiated degree, and the relations of Cx expression with metastatic potential of gastric cancer were analyzed.
RESULTS: Immunohistochemistry showed that the positive staining of Cx32 and Cx43 was located at cell membrane and cytoplasm, and the positive rate of Cx expression was significantly higher in normal gastric tissues than that in cancer tissues (Cx32: χ2 = 23.1,P < 0.05; Cx43: χ2 = 11.6, P <0.05). The positive rate of Cx expression was markedly higher in well-differentiated gastric cancer tissues than that in poorly-differentiated cancer ones (Cx32: χ2 = 32 ......
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