当前位置: 首页 > 期刊 > 《世界华人消化杂志》 > 2006年第7期
编号:11123984
树突状细胞和调节性T细胞在自身抗原所致小鼠免疫耐受模型中的作用
http://www.100md.com 向 明, 张程亮, 邹晓蕾, 蔡晓寒, 彭佳蓓
闂佺ǹ绻戞繛濠囧极椤撶姵瀚氱€广儱绻掔粣锟�自身抗原;树突状细胞;调节性T细胞;1型糖尿病,向明,张程亮,邹晓蕾,蔡晓寒,彭佳蓓,向明,通讯作者:,Rolesofdendrit
第2页
第1页


    参见附件(943KB,6页)。

     向明, 张程亮, 邹晓蕾, 蔡晓寒, 彭佳蓓, 华中科技大学同济医学院药学院药理教研室 湖北省武汉市 430030

    向明, 女, 湖南溆浦人, 华中科技大学同济医学院药学院药理教研室副教授, 博士, 主要从事免疫药理学即自身免疫病发病机制和治疗方法研究.

    国家自然科学基金资助项目, No.30200343

    通讯作者: 向明, 430030, 湖北省武汉市, 华中科技大学同济医学院药学院药理教研室. xiangming@mails.tjmu.edu.cn

    电话: 027-83657813 传真: 027-83692892

    收稿日期: 2006-01-10 接受日期: 2006-02-08

    Roles of dendritic cells and regulatory T cells in autoantigen-induced murine immune tolerance model

    Ming Xiang, Cheng-Liang Zhang, Xiao-Lei Zou, Xiao-Han Cai, Jia-Bei Peng

    Ming Xiang, Cheng-Liang Zhang, Xiao-Lei Zou, Xiao-Han Cai, Jia-Bei Peng, Department of Pharmacology, College of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China

    Supported by National Natural Science Foundation of China, No. 30200343

    Correspondence to: Ming Xiang, Department of Pharmacology, College of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. xiangming@mails.tjmu.edu.cn

    Received: 2006-01-10 Accepted: 2006-02-08

    Abstract

    AIM: To investigate the important roles of dendritic cells (DC) and CD4+CD25+ regulatory T cells in immune prevention against insulin dependent diabetes (IDDM) by autoantigen insulin administration.

    METHODS: The model of IDDM was established by intraperitoneal injection of low-dose streptozotocin (STZ) 40 mg/kg per day for 5 consecutive days in Balb/c mice. The bovine insulin (100 μg) in incomplete Freund's adjuvant (IFA, emulsified 1∶1) was given subcutaneously to the mice weekly for 4 weeks. The blood glucose was examined once a week and all the mice were killed after 5 weeks. Pancreas tissues were collected for histopathological examination. DC precursor cells from bone marrow and lymphocytes from spleen were isolated. The phenotype of DC and CD4+ CD25+ regulatory T cells were analyzed by fluorescence activated cell sorter (FACS) ......

您现在查看是摘要介绍页,详见PDF附件(943KB,6页)
濡傛灉鎮ㄥ湪浣跨敤鎵嬫満绛夋祦瑙堟椂鏃犳硶鏌ョ湅鎴栦笅杞藉叏鏂囷紝鍙兘鏄鎼滅储寮曟搸澶辩湡鈥滆浆鐮佲€濓紝璇风偣鍑诲睆骞曟渶涓嬫柟鐨勨€滅數鑴戠増鈥濇垨鈥滃師缃戦〉鈥濊闂€�


闄愪簬鏈嶅姟鍣ㄥ帇鍔涳紝缃戠珯閮ㄥ垎淇℃伅鍙緵鐖卞績浼氬憳鎴栨湁涓€瀹氱Н鍒嗙殑娉ㄥ唽浼氬憳娴佽銆�
姝� pdf鍏ㄦ枃 闇€瑕� 5 绉垎锛堝厤璐规敞鍐岀櫥褰曞悗姣忓ぉ鍙互棰嗗彇10涓Н鍒�锛夈€�
    娣団剝浼呮禒鍛返閸欏倽鈧喛绱濇稉宥嗙€幋鎰崲娴f洑绠e楦款唴閵嗕焦甯归懡鎰灗閹稿洤绱╅妴鍌涙瀮缁旂姷澧楅弶鍐ㄧ潣娴滃骸甯拋妞剧稊閺夊啩姹夐敍宀冨閹劏顓绘稉鐑橆劃閺傚洣绗夌€规粏顫﹂弨璺虹秿娓氭稑銇囩€硅泛鍘ょ拹褰掓鐠囦紮绱濈拠鐑藉仏娴犺埖鍨ㄩ悽浣冪樈闁氨鐓¢幋鎴滄粦閿涘本鍨滄禒顒佹暪閸掍即鈧氨鐓¢崥搴礉娴兼氨鐝涢崡鍐茬殺閹劎娈戞担婊冩惂娴犲孩婀扮純鎴犵彲閸掔娀娅庨妴锟�

   瀵邦喕淇婇弬鍥╃彿  閸忚櫕鏁為惂鐐  鐠囧嫯顔戦崙鐘插綖  閹兼粎鍌ㄩ弴鏉戭樋