克拉霉素_____电荷转移反应;(期刊论文)

荷移分光光度法测定克拉霉素

http://www.100md.com 《第四军医大学学报》 2004年第23期

克拉霉素,,电荷转移反应;,茜素;克拉霉素;分光光度法,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Spectrophotometric determination of clarithromycin based on charge transfer reaction between clarithromycin and alizarin

    LI HuaKan, WANG QiaoFeng, ZHAO Yan

    1Department of Chemistry，Jinzhou Medical College, Jinzhou 121001，China, 2Department of Chemistry, School of Pharmaceutics, Fourth Military Medical University, Xi’an 710033, China

    【Abstaract】 AIM: To establish a method for rapidly determinating the content of clarithromycin in preparation. METHODS: To utilize visible spectrophotometry based on the charge transfer reaction between clarithromycin as donor and alizarin as acceptor in alcoholwater solution. RESULTS: The apparent molar absorptivity of complex was 7.31×103 L/(mol·cm) at 546 nm, while the composition ratio and stability constant of charge transfer complex were 1∶1 and 3.4×104 respectively. Beer’s law was strictly obeyed in the range of 1-100 mg/L of clarithromycin. The average recovery was over 98.0%. The average standard deviation of six determinations was 1.30% when the concentration of clarithromycin was 50 mg/L. CONCLUSION: The proposed method is stable, accurate, sensitive and rapid, which can contribute to satisfactory results for the determination of clarithromycin in preparation. ......

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