Serial diffusionª²weighted MR imaging and 1Hª²MRS around hematoma in pigs with frontal lobe hemorrhage

    ZHANG Xinª²Jiang, YANG Jinª²Sheng, CHANG Liª²Ying, YIN Xiaoª²Ping, WANG Wei, ZHANG Suª²Ming, FANG Siª²Yu

    1Department of Neurology, Lanzhou General Hospital, Cinese PLA Lanzhou Command, Lanzhou 730050, China, 2Department of Neurology, 3Department of MRI, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, China

    ¡¾Abstract¡¿ AIM: To determine the characteristics of perilesion edema during 1-7 days in pigs with intracerebral hemorrhage (ICH). METHODS: With injection of 2.5 mL autologous artery blood into right frontal lobes, 15 pigs (10-15 kg) had fluidª²attenuated inversionª²recovery (FLAIR), diffusion weighted imaging (DWI) and 1Hª²magnetic resonance spectrum (1Hª²MRS) by 1.5 T MR at 24 hours (n=15), at 72 hours (n= 9) and on day 7 (n=5). In 4 animals, bloodª²brain barrier permeability was observed by leakage of Evan¡¯s blue at 24 hours (n= 4). RESULTS: The edema was located around hematoma on the sequence of FLAIR at 24 hours after ICH. The perilesional apparent diffusion coefficiency (ADC) increased and no lactic acid peak was observed by 1Hª²MRS from 24 hours to day 7 in all the animals but one. CONCLUSION: During 1-7 days after ICH, the vasogenic edema dominates around the hematoma. Only in case of massive hemorrhage, ischemia may coexist. ......