关键词: CD44;宫颈肿瘤;免疫组织化学

    摘 要:目的 探讨CD44v6在宫颈癌前病变及宫颈癌中的表达及其临床意义. 方法 应用S-P免疫组化法观察宫颈癌60例、正常宫颈上皮组织10例和宫颈上皮内瘤样病变(CIN)12例中CD44v6的表达. 结果 正常宫颈上皮组织中CD44V6阳性率为20%，CIN中CD44v6阳性率为42%，而宫颈癌组织中CD44v6阳性率为68%.在宫颈癌中，随病理分级的升高，CD44v6表达增加，其Ⅰ，Ⅱ及Ⅲ级CD44v6阳性率分别为43%，69%和85%(P<0.05).CD44v6表达在有淋巴结转移组中(91%)明显高于无淋巴结转移组(52%，P<0.05).临床分期晚CD44v6表达高，Ⅰ，Ⅱ期和Ⅲ，Ⅳ期CD44v6阳性率分别为63%和80%，但无统计学意义(P>0.05). 结论 随着宫颈癌的发生、发展，CD44v6表达率逐渐增加，CD44v6可作为判断宫颈癌恶性程度、转移及预后的重要指标.

    CD44v6expression and its significance in cervical cancer tissue

    SUN Hong，HAN Su-Xia，XIAO Ju-Xiang，NAN Ke-Jun，LI Ming-Zhong

    Department of Oncology，First Hospital of Xi'an Jiaotong Univesity，Xi'an710061，China

    Keywords:CD44;cervix neoplasms;immunohistochemistry

    Abstract:AIM To Study the clinical significance of CD44v6expression in cervical cancer.METHODS Specimens of60cervical cancer，10normal cervical epithelia and12cervical intraepithelial neoplasia(CIN)were examined for CD44v6expression by immunohistochemical staining.RESULTS Positive staining was seen in20%of normal cervical epithe-lia ......