关键词: 黑质致密部;自发放电;去甲肾上腺素;敏感性;非稳定周期轨道

    摘 要:目的 研究黑质致密部(SNc)神经元的放电型式与其对去甲肾上腺素(NE)敏感性的关系，探讨“非周期敏感”现象的普遍性. 方法 在幼鼠的脑片胞外记录SNc神经元的自发放电.比较周期与非周期放电神经元对NE反应的敏感性，对非周期放电神经元的放电进行非线性动力学分析. 结果 NE对18个周期及12个非周期放电神经元呈现兴奋作用，对16个周期及12个非周期放电神经元呈现抑制作用.无论兴奋或抑制作用，非周期放电神经元对不同浓度NE的反应程度均比周期放电神经元大(P<0.01);NE的兴奋及抑制作用可分别被酚妥拉明(20μmol L-1 )及舒必利(1μmol L-1 )阻断;在非周期放电神经元的放电序列中测出非稳定周期轨道. 结论 SNc的非周期放电神经元比周期放电神经元对NE更敏感，这种敏感性可能与非周期放电的混沌特性有关.

    Relationship between sensitivity to norepinephrine and firing pattern of substantia nigra compacta neu┐rons

    LIU Guo-Peng，HU San-Jue，HAN Sheng，WANG Xiao-Bin，YANG Hong-Jun

    Institute of Neurosciences of Chinese PLA，Fourth Military Medical University，Xi'an710033，China

    Keywords:substantia nigra compacta;spontaneous activity;norepinephrine;sensitivity;unstable period or-bits

    Abstract:AIM To study relationship between the firing pattern and sensitivity of substantia nigra compacta neurons to norepinephrine，to certify universality of“non-period sensitivity”in nervous system.METHODS Spontaneous ac-tivities of substantia nigra compacta neurons in brain slice of young rats were recorded extracellularly ......