宫颈肿瘤_____宫颈肿瘤；HLA抗原(期刊论文)

宫颈癌与HLA等位基因DQB1*03、DR15的相关性研究

http://www.100md.com 《第四军医大学学报》 2004年第24期

宫颈肿瘤,,宫颈肿瘤；HLA抗原,0引言,1对象和方法,2结果,3讨论,【参考文献】

     Study on relationship between cervical cancer and HLADQB1*03 and DR15 alleles

    XIA Lin,ZHANG Ju,CHEN ZhongChan,BAI YuJie,LUO Jin,YANG Hao,YAN XiaoJun

    PLA Institute of Genetic Diagnosis,Administration of Scientific Research,Fourth Military Medical University,Xian 710033,China

    【Abstract】AIM： To investigate the relationship between the susceptibility to cervical cancer and HLADQB1*03 and DR15 alleles in Shaanxi Province. METHODS: The target DNA fragments of HLADQB1*03 and DR15 alleles (79 and 197bp respectively) were amplified by using polymerase chain reaction of sequence specific primers(PCR-SSP)in cervical cancer patients and healthy control in Shaanxi Province. RESULTS: The frequency of the DQB1*03 allele was significantly higher in cervical cancer patients than that in normal controls, while no significant difference was found in the frequency of the DR15 allele between the patient group and the control group. CONCLUSION: There may be some correlation between the development of cervical cancer and HLA-DQB1*03, and no correlation between the development of cervical cancer and HLA-DR15. ......

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