关键词: CD44v6;卵巢肿瘤;免疫组织化学

    摘 要:目的 探讨上皮性卵巢肿瘤中CD44v6的表达及临床意义. 方法 采用SABC免疫组织化学方法，检测了72例上皮性卵巢肿瘤中CD44v6的表达状况. 结果 恶性卵巢肿瘤、交界性肿瘤及良性肿瘤中CD44v6的表达分别为44.4%，20.0%和11.8%.恶性卵巢肿瘤中CD44v6的表达较良性肿瘤明显增高(P<0.05)，恶性肿瘤中有淋巴结转移者的CD44v6表达(67.0%)与无淋巴结转移者(33.0%)相比有显著差异(P<0.05).CD44v6高表达患者的生存期缩短.在恶性卵巢肿瘤不同病理分级及临床分期间CD44v6表达无明显差异(P>0.05). 结论 CD44v6在上皮性恶性卵巢肿瘤中的发生及淋巴结转移过程中可能起重要作用，并有望成为判断患者预后的有效指标.

    Expression and significance of metallothioneine gene in epithelial ovarian tumor

    YAN Rui-Lan，XIN Xiao-Yan，WANG Jian，WANG De-Tang

    Department of Obstetrics and Gynaecology，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China

    Keywards:CD44v6;ovarian neoplasm;immunohis-tochemistry

    Abstract:AIM To examine the expression of CD44v6in ovarian tumor and to explore its relationship with occurrence of ovarian tumor.METHODS CD44v6expression in72samples of ovarian tumor was observed by SABC immunohis-tochemical staining.RESULTS The positive rates of CD44v6expression among malignant ......