霍奇金淋巴瘤CD99基因表达缺失的意义
霍奇金淋巴瘤,,霍奇金淋巴瘤;,免疫组织化学;,CD99基因,0引言,1材料和方法,2结果,3讨论,【参考文献】
Expression of CD99 in classical hodgkin’s lymphomaLI XianMao, LI Yan,ZHAO Tong, ZHU MeiGang,ZHANG JingHua
1Department of Pathology, Southern Medical University, Guangzhou,510515, 2The 6th Department of Internal Medicine, People’s Hospital, Tibetan Autonomous Region, Lasa 850000, China
【Abstract】 AIM: To study the expression of CD99 of ReedSternberg cells in classical Hodgkin’s lymphoma (cHL). METHODS: Eight cHL cases were confirmed according to the new WHO pathological classification. Immunohistochemistry for CD99 was performed with SABC method, and the CD99 expression of cell lines was tested by flow cytometer. RESULTS: The positive expression of CD99 was 0% (0/8). The CD99 expression of DG75 and Jurkat cell lines was (87.3±0.4)% and (96.8±0.6)%, and the CD99 expression of L428 cell line was (3.8±0.4)%. The CD99 expression of HDLM2 cell line was (66.4±0.3)%. CONCLUSION: Downexpression of CD99 in HRS cells may be a useful index for the diagnosis of classical Hodgkin’s lymohoma. ......
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