(广东省韶关粤北第二人民医院， 广东 韶关 512026)

    摘 要：目的：评价泮托拉唑对肝源性溃疡(HU)的疗效。方法：对238例肝硬化经胃镜检查出溃疡的44例患者，予每日晨服泮托拉唑40mg，疗程4～6周，着重观察胃镜下溃疡愈合情况，并与同期消化性溃疡(PU)疗效对比分析。结果：4周愈合率HU组中，十二指肠溃疡(DU)为74.1%(20/29)，胃溃疡(GU)为53.3%(8/15)；PU组中DU为96.7%(29/30),GU为100%(9/9)，两组比较差异有非常显著性(P<0.01)。6周愈合率HU中DU为86.2%(25/29)，GU为86.7%(13/15)。肝功能Child C级者溃疡愈合率明显降低。结论：泮托拉唑治疗HU疗效满意，但疗程较PU长，HU的愈合率C级患者较低。

    关键词： 泮托拉唑； 肝源性溃疡； 疗 效

    Effect of Pantoprazole in the treatment of hepatogenous ulcer

    NING Xiao-yan, TANG Meng-xuan, CHEN Xing-hao

    (The Second People's Hospital of Yuebei,Guangdong Shaoguan 512026, China)

    Abstract： Objective： To evaluate the effect of pantoprazole in the treatment of hepatogenous ulcer (HU). Method： Forty-four patients of HU recieved pantoprazole 40mg once a day for 4～6 weeks.The healing rates of HU was observed by endoscopy in comparation with peptic ulcer(PU). Result： In patients of HU,the overall healing rates for DU at 4 weeks was 74.1%(20/29),the rates for GU at 4 weeks 53.3%(8/15).In patients of PU,the overall healing rates for DU at 4 weeks was 96.7%(29/30),the rates for GU at 4 weeks 100%(9/9),with significant difference (p<0.01) comprared to PU group.In patients of HU, the overall healing rates for DU and GU at 6 weeks was 86.2%(25/29),86.7%(13/15),respectively. Conclusion： Our data showed the effect of pantoprazole in treatment of HU was satisfactory, but the course of treatment was longer compare to patients of PU. However, the healing rates in patients with Child C group was relatively low. ......