Distribution and drug resistance of pathogens in respiratory tract of patients with acute explosion chronic obstructive pulmonary disease

    WANG Yongª²Xing, CAO Jiaª²Yue, GUO Mei, XIE Baiª²Mei, LIU Deª²Jiang, LIU Zhenª²Xia

    Department of Respiratory Diseases, PLA No. 451 Hospital, Xi¬ðan 710054, China

    ¡¾Abstract¡¿ AIM: To analyze the distribution of pathogens in respiratory tract and their drug resistance in the patients with acute explosion chronic obstructive pulmonary disease (AECOPD) for a better use of antibiotics in treatment. METHODS: The sputum samples of 240 AECOPD patients from January 2002 to May 2004 were collected from our hospital and the pathogen¬ðs species in all samples were tested. The drug sensitivity was determined by slip diffusion method. RESULTS: 114 strains of pathogens were found in all sputum samples. 66.7% of them were Gramª²negative, 24.6% were Gramª²positive and 7.0% were epiphytes. Among the Gramª²negative bacillis, the main pathogens included Pseudomonas (28.1%), Haemophilus influenza (15.8%), enteric bacilli (12.3%), and Klebsiella pneumoniae (8.8%). Among the Gramª²positive coccis, the main pathogens included Staphyloccus aureus (12.3%), Pneumococcus (7.0%) and Staphyloccus epidermindis (5.3%). The results of drug sensitivity test showed that most of the Gramª²negative bacillis were more sensitive to ticarcilli/clavulanate potassium, imipenem, ceftazidime, piperacillin and amikacin, and that most of the Gramª²positive coccis were more sensitive to imipenem, ceftazidime and vancomycin. CONCLUSION: Gramª²negative bacillus are predominant in lower respiratory tract in AECOPD patients with higher frequency of drug resistance. The 3rd or 4th generation of cephalosporins and some antibiotics with the capability of inhibiting ESBLS are recommended in clinical application. ......