蛇床子素的药理学研究进展
蛇床子素,,蛇床子素；香豆素；药理作用,1药动学研究,2药效学研究,3结论,参考文献：
摘要：目的：综述蛇床子素的药理作用。方法：根据近十年的中外文献和相关成果，从药理作用及其作用机制等方面作以阐述。结果与结论：蛇床子素的药理作用广泛，在抗氧化、抗肿瘤和对心血管疾病和绝经期骨质疏松症的治疗等具有潜在的开发应用价值。关键词：蛇床子素；香豆素；药理作用
Research Advances in Pharmacological Function of Osthole
LIU Jianxin, LIAN Qishen
(Gannan Medical College, Ganzhou, Jiangxi 341000, China)
Abstract:Objective:To summarize the pharmacological function of osthole.Methods:Based on the documents and achievements in recent 10 years, the pharmacological function and its mechanism were summed up.Results and Conclusion:The efficacy of osthole is versatile. It predicts that osthole has potential application values in the effects of anti-oxidation, anti-tumor and in the therapy of cardiovascular diseases and menopausal osteoporosis as well.
Key words:Osthole; Coumarin;Pharmacological effects
蛇床子Cnidium monnieri(L) Cuss.是伞形科蛇床干燥成熟果实。药用历史悠久，出土于马王堆三号汉墓，距今已有2000多年的《养生方》中就有记载蛇床子温肾作用，以蛇床配干姜、肉桂等辛热之品，治妇人阴寒。后来在《神农本草经》中将其补虚作用总结为“主男子阴虚，久服轻身”。李时珍在《本草纲目》中进一步阐明蛇床子的作用 “蛇床乃右肾命门、少阳，三焦气分之药。神农列之为上品，不独补助男子，而又有益妇人”。其主要活性成分为蛇床子素(osthole,ost)，它的化学名为7甲氧基8异戊烯基香豆素(7-methoxy-8-[3-methylpent-2-enyl]coumarin) ......
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