持续性钠流__(期刊论文)

受损背根节神经元持续性钠流的检测

http://www.100md.com 《第四军医大学学报》 2004年第20期

持续性钠流,,神经节，脊；膜片钳术；持续性钠流；阈下膜电位振荡,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Detection of persistent sodium current in injured DRG neurons

    LIU ZhiYang, WANG YuYing, WANG WenTing, HU SanJue

    PLA Institute of Neuroscience, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To detect persistent sodium current and to study its relationship with subthreshold membrane potential oscillation in injured DRG neurons. METHODS: Wholecell patchclamp experiments were performed with medium and small DRG neurons freshly isolated from rats. RESULTS: In the voltageclamp, DRG neurons with depolarizated membrane potential from -80 mV to -30 mV in ramp, produced a persistent sodium current for 150200 ms. The current with amplitude of 89200 pA was sensitive to 100 nmol/L TTX. In the currentclamp, when 100 nmol/L TTX was added to the cells with subthreshold membranepotential oscillation (SMPO), the oscillation disappeared. CONCLUSION: The INap detected in the injured DRG neurons may be in some way responsible for the production of SMPO. ......

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