中晚期鼻咽癌后程加速超分割放疗的近期疗效观察
中晚期鼻咽癌,,中晚期鼻咽癌；后程加速超分割放疗；近期局部疗效,1材料与方法,2结果,3讨论,参考文献:
(新疆医科大学附属肿瘤医院放疗三科，新疆乌鲁木齐830011)摘要: 目的: 观察鼻咽癌后程加速超分割放射治疗(LCAF)的近期疗效和毒性反应。方法：60例鼻咽癌患者随机分为常规分割放射治疗(CF)组和LCAF组，CF组患者鼻咽部和颈部全程行常规分割放疗， LCAF组先常规放疗36 Gy，25 d，然后采用LCAF照射33～35 Gy，16～18 d，每日2次，间隔时间6 h，鼻咽部剂量为65～75 Gy。有颈部淋巴结转移者颈部照射剂量68～74 Gy，无颈部淋巴结转移者预防照射剂量55～60 Gy。放射治疗结束时、放疗结束后3个月复查鼻咽部CT、纤维鼻咽镜、颈部CT和/或B超检查，综合评价放疗疗效。结果：放疗结束后3个月LCAF组肿瘤全部消退率为79.31%，CF组为54.84%，差异有统计学意义(χ2=4.038 0, P<0.05)，LCAF组与CF组比较，Ⅰ、Ⅱ、Ⅲ度急性放射反应发生率差异无统计学意义(χ2=0.202 0, P>0.05)。结论: LCAF放射治疗可以改善中晚期鼻咽癌的局部控制率，而不增加急性放射反应。
关键词: 中晚期鼻咽癌；后程加速超分割放疗；近期局部疗效
Preliminary report of late course accelerated hyperfractionated radiotherapy for advanced nasopharyngeal carcinoma
Simayili·Maimaitiniyazi, Munire·Mushajiang, CHENG Fang, et al
(Third Department of Radiation Oncology, Affiliated Cancer Hospital, Xinjiang Medical University, Urumqi 830011, China)
Abstract: Objective: To evaluate the immediate response and radio toxicity of late course accelerated hyperfractionated radiotherapy for advanced nasopharyngeal carcinoma. Methed: From June 2001 to December 2002, 60 patients with advanced nasopharyngeal carcinoma were devided into conventional fractionation (CF) and late course accelerated hyperfractionated radiotherapy (LCAF) groups. Thirtyone patients in CF group received conventional radiotherapy. Twentynight patients in LCAF group were treated with the same fractionation as CF group until the dose of 36Gy, and then followed by late course accelerated hyperfractionated radiotherapy:1.21.3 Gy/f, twice daily with 68 hour interval between the two fractions, to the total dose of 6575Gy in 4147days. Results: The complete response rate was 79.31% in the LCAF group and 54.84% in the CF group after 3 months of radiotherapy. The difference is significant between two groups, but without finding any significant difference in acute radio toxicity .Conclusion: LCAF radiotherapy can improve local control of nasopharyngeal carcinoma and does not increase the acute radio toxicity. ......
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