摘要：目的：研究DPC4(Smad4)蛋白在胃癌的表达及临床意义。方法：应用免疫组化SP法,对40例胃癌及20例癌周粘膜进行检测,并结合临床资料进行研究。结果：胃癌DPC4(Smad4)蛋白的表达阳性率为75%(30/40), 20例癌周粘膜内DPC4(Smad4)蛋白均呈强阳性表达,两者比较差异有显著性意义(P<0.05)。DPC4蛋白在胃癌的表达与患者年龄、发生部位无关(P>0.05)，而与临床分期、淋巴结转移、病理分级、肿物大小有关性(P<0.01)。结论：DPC4(Smad4)蛋白的表达与胃癌的发生发展密切相关，对预后的判断有参考价值。

    关键词： 胃癌； DPC4基因； 免疫组化

    Expression and Significance of DPC4 in Gastric Cancer

    SHAO Yun-xia, QU Yan-gang, ZHU Wen-di

    (The Second Affiliated Hospital to Medical College of Qingdao University, Shandong Qingdao 266042, China)

    Abstract: Objective: To investigate the expression of DPC4 in gastric cancer and evaluate its clinical significance. Methods: DPC4 was measured in 80 cases of gastric cancer tissues and 20 cases of benign disease by immunohistochemistry SP method using monoclonal antibody to their protein.Results: The expression of DPC4 in breast cancer was 75%(30/40). There was significantly higher than that in benign disease. Their expression was not related to gender and position of the disease (P>0.05), but related to pathology stage clinical stage, lymph node metastasis and tumor sides (P<0.01).Conclusion: The expression of DPC4 was closely correlated with the gastric cancer and more valuable about predicting. ......