摘要:目的:观察养血清脑颗粒配合针刺治疗血管性痴呆(vascular dementia，VD)患者的临床疗效并探讨其治疗机制。方法:99例VD患者随机分为两组:治疗组采用养血清脑颗粒配合针刺治疗，对照组给予脑复康治疗。治疗前后进行智力量表、生活自理能力等评分，并观察脑动脉平均血流速度(VM)、血浆一氧化氮(NO)和内皮素(ET)水平的变化。结果:①养血清脑颗粒配合针刺能显著改善VD患者的临床症状，治疗后两组比较差异有显著性(P<0.01或P<0.05)。②与治疗前比较，治疗组治疗后血浆NO显著增高(P<0.01) ,ET水平和VM显著下降(P<0.01)，对照组上述指标无显著变化。结论:养血清脑颗粒配合针刺治疗血管性痴呆有较好疗效，调控血管活性物质是其作用的主要机制。

    关键词: 血管性痴呆； 养血清脑颗粒配合针刺； 一氧化氮； 内皮素

    Clinical Study Of Yangxue Qingnao Granule and Needing(YXQNN) in Treating Vascular Dementia

    WANG Guang

    (Zaozhuang Health School， Shandong Zaozhuang 277101, China)

    Abstract: Objective: To observe the clinical therapeutic effect of Yangxue Qingnao granule and Needing in treating vascular dementia (VD) and to explore its mechanisms.Methods: Ninety-nine patients with VD were randomly divided into the treated group and the control group ，treated with YXQNN and Piracetam respectively. To observe the changes before and after treatment in the mini-mental state examination(MMSE) and activity of daily living(ADL)scoring ......