阿尔茨海默病__(期刊论文)

侧脑室注射链脲霉素引起大鼠脑Aβ140和Aβ142表达增加

http://www.100md.com 《第四军医大学学报》 2005年第15期

阿尔茨海默病,,阿尔茨海默病；侧脑室注射；β淀粉样蛋白,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Expression of Aβ140 and Aβ142 after intracerebroventricular injection of streptozotocin in rats

    CHU WenZheng, QIAN CaiYun

    Department of Neurology, First Hospital, SUN Yatsen University, Guangzhou 510080, China

    【Abstract】 AIM: To investigate the effect of intracerebroventricular administration of streptozotocin (STZ) on expression of Aβ in rat brain. METHODS: Twentyfour adult SpragueDawleyer rats were divided into 2 groups randomly (n=12). The rats in the operation group received intracerebroventricular injection of STZ bilaterally with a dose of 3 mg/kg and the injection was repeated on the third day. The rats in the sham operation group received the same treatment as the first group except for STZ injection. Twenty one days later, immunohistochemical method was used to investigate the expression of Aβ140 and Aβ142. RESULTS: After intracerebroventricular injection of STZ, the expression of A β140 and Aβ142 increased in both the cortex and hippocampus in rat brain. CONCLUSION: Expression of Aβ increase after intracerebroventricular injection of STZ, indicating that the disturbance of insulin/insulin receptor system may play an important role in the pathogenesis of Alzheimers disease. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/03/12/94/80/53.htm

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