Effect of venous hypertension on cerebral blood flow in rats

    KUAI Jianª²Ke, CHAI Wei, YU Daiª²Hua, YAO Liª²Nong, ZHANG Fengª²Lin, ZHAO Hui

    Department of Anesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi¬ðan 710038, China

    ¡¾Abstract¡¿ AIM: To evaluate the changes of regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV) in chronic venous hypertension models of rats. METHODS: Venous hypertension was induced by an endª²toª²end anastomosis between the right carotid artery and the right external jugular vein in 20 rats. rCBF and rCBV were assessed by laser Doppler scanning before and after the anastomosis. The region of anastomosis was ligated 2 weeks later and rCBF and rCBV were measured again. RESULTS: Compared with the data before anastomosis, rCBF and rCBV of the left hemisphere did not change. However, in the right hemisphere, rCBF and rCBV significantly increased from (41.9¡À10.5) and (1245.1¡À710.2) to (43.4¡À10.3) and (1561.5¡À850.1) (P<0.05), respectively. rCBV significantly increased to (1737.9¡À1041.8) 2 weeks after the bypass but recovered to (1000.7¡À698.5) after clipping the fistula (P<0.05) and rCBF significantly decreased to (34.5¡À8.3) 2 weeks after the bypass but recovered to (38.9¡À6.2) after clipping the fistula (P<0.05). CONCLUSION: The rat model with an endª²toª²end anastomosis between a common coronery artery and a homolateral external jugular vein is clinically useful in studying the pathophysiology of chronic venous hypertension. Venous ischemia is reversible, which can be improved by appropriate early treatment. ......