慢性胃炎__(期刊论文)

幽门螺杆菌相关性胃炎中核因子κB与IL8表达的意义及关系

http://www.100md.com 《第四军医大学学报》 2005年第15期

慢性胃炎,,核因子κB；白细胞介素8；幽门螺杆菌；慢性胃炎,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Expression of NFκB and interleukin8 in helicobacter pyloriassociated gastritis

    CAO Ping, LU QiMing, ZHANG XiuLan

    1School of Clinical Medicine, Lanzhou University, 2Department of Gastroenterology, Peoples Hospital of Gansu Province, Lanzhou 730000, China

    【Abstract】 AIM: To investigate the relation and distribution of expressions of nuclear factorκB (NFκB) p65 protein and interleukin8 (IL8) in helicobacter pyloriinfected gastric mucosa. METHODS: Gastric mucosal biopsy specimens were obtained respectively from 38 patients with H.pyloripositive gastritis and 18 H.pylorinegative control subjects. The expressions of NFκB p65 protein, IL8 mRNA and protein were determined by immunohistochemistry and in situ hybridization. RESULTS: The expressions of p65 protein, IL8 mRNA and protein were significantly higher in H.pyloripositive gastric mucosa than those in H.pylorinegative controls (5.7±3.3 vs 3.0±2.5, 3.7±2.6 vs 1.1±1.3, 4.0±3.0 vs 1.9±1.6, P<0.01) and they were correlated with the histological severity of activity, inflammation and H.pylori density (P<0.05). The expression of p65 significantly was correlated with that of IL8 mRNA and protein (P<0.01). There was a positive correlation between IL8 mRNA and IL8 protein (P<0.01). CONCLUSION: H.pylori infection leads to the overexpression of NFκB p65 and IL8 in the gastric mucosa. NFκB activation may contribute to IL8 gene transcription and is involved in the pathological process of H.pyloriassociated gastritis. ......

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