宫颈癌_____COX2;_PGs;_宫颈癌;

COX2和PGs在宫颈上皮内瘤样变和宫颈癌组织的表达及意义

http://www.100md.com 《第四军医大学学报》 2005年第13期

宫颈癌,,COX2;,PGs;,宫颈癌;,致癌机制,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Expression of COX2 and PGs in CIN and cervical carcinoma and its significance

    PENG YunHua, DAI YinMei

    Department of Obstetrics and Gynecology, First Hospital of Lanzhou Univesity, Lanzhou 730000, China

    【Abstract】 AIM: To investigate the expression of COX2 and PGs in cervical intraepithelial neoplasia (CIN) and cervical carcinoma and to study the possible relationship in carcinogenesis. METHODS: Tissue and blood samples were harvested respectively from 20 normal, inflammation, CIN women and 40 cervical carcinoma women. The expression of COX2 was detected by RTPCR and immunohistochemistry SP method, and the PGs levels were detected by RIA. RESULTS: The overall positive expression of COX2 and the level of PGs were higher in inflammation, CIN and cervical carcinoma than those in normal cervix (P<0.01). CONCLUSION: COX2 and PGs may be involved in the development of inflammatoryCINcarcinoma and COX2 accelerates the progress of the tumor by regulating the level of PGs.

    【Keywords】 COX2; PGs; cervical carcinoma; carcinogenesis ......

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