药动力学_____药动力学;脑转移;放射治疗;磁共振影像

药动力学MRI对肺腺癌脑转移放疗疗效的评估

http://www.100md.com 《第四军医大学学报》 2005年第13期

药动力学,,药动力学;脑转移;放射治疗;磁共振影像,0引言,1对象和方法,2结果,3讨论,【参考文献】

     Pharmacokinetic MRI for assessing response of brain metastases to radiotherapy for lung adenocarcinoma

    CAI Kui, CHEN Min, WANG WenChao, ZHANG Chen, LI GuoZhen

    Department of Radiology, Beijing Hospital, Ministry of Health, Beijing 100730，China

    【Abstract】 AIM: To evaluate the response of brain metastases of lung adenocarcinoma to radiotherapy with tissue pharmacokinetic MRI. METHODS: Eleven clinically confirmed cases of lung adenocarcinoma, with a total of 40 brain metastatic foci, were examined with routine and pharmacokinetic MRI techniques at 3 time points respectively: Before radiotherapy, 3-4 weeks after radiotherapy and 18-24 weeks after radiotherapy. The average values of dynamic enhancement of the 40 foci were calculated at 37 seconds (after contrast injection). RESULTS: The average value of the 40 foci was (69±23)% before radiotherapy, (32±7)% 3-4 weeks after radiotherapy and (11±6)% 18-24 weeks after radiotherapy. CONCLUSION: Pharmacokinetic MRI proves to be a quantitative indicator for the response of brain metastasis to the radiotherapy for lung adenocarcinoma. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/03/12/94/83/43.htm

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