肝疾病_____S腺苷甲硫氨酸；肝疾病，酒精性；肝

腺苷蛋氨酸对大鼠乙醇肝损伤的预防作用

http://www.100md.com 《第四军医大学学报》 2005年第23期

肝疾病,,S腺苷甲硫氨酸；肝疾病，酒精性；肝,损伤,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Preventive effect of SadenosylLmethionine from alcoholic liver injury in rats

    LI Tao, ZHANG YongQiang, LIU LiBing, YU Jun, CHEN JianKang, WU Hao

    1Team 10, Cadet Brigade, 2Center of Teaching & Experiment, School of Basic Medicine, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To investigate the protective effects of SadenosylLmethionine (SAM) on alcoholic liver diseases. METHODS: Seventeen SD rats were randomly divided into 3 groups: alcohol control group, highdosage SAM group and lowdosage SAM group. Control group was only fed intragastrically with alcohol 6 mL/(kg·d) to establish the alcoholic liver injury model. The high and lowdosage SAM groups were injected with SAM at the dosage of 16 mg/(kg·d) and 32 mg/(kg·d) respectively before they were fed intragastrically with alcohol [6 mL/(kg·d)] to observe the preventative effect. All the rats were killed on the 26th day. γGT was examined and liver pathological sections were observed. RESULTS: The increasing trend of γGT in serum was significantly inhibited[(72±16) nkat/L vs (2437±362) nkat/L, P<0.01；(88±8) nkat/L vs (2437±362) nkat/L, P<0.05]. The histopathology showed that SAM had some protective effects on the liver function. CONCLUSION: SAM can reduce the alcoholrelated injury of liver. ......

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