胰岛细胞_____胰岛细胞；低密度脂蛋白；维生素E,C

低密度脂蛋白对胰岛细胞功能的影响

http://www.100md.com 《第四军医大学学报》 2005年第13期

胰岛细胞,,胰岛细胞；低密度脂蛋白；维生素E,C,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Effect of low density lipoprotein on islet cell function

    TIAN LiMin, LIU Jing, GAO CuiXia

    Department of Endocrine Secretion, Gansu Provincial Peoples Hospital, Lanzhou 730000, China

    【Abstract】 AIM: To study the effect of low density lipoprptein (LDL) on the function of islet cell in vitro. METHODS: Wistar rat islet cells were isolated for cell culture and treated with LDL (from 8 mg/L on) for 48 h. The cells were cultured with low glucose (2.8 mmol/L) and high glucose (16.7 mmol/L). Insulin secretion of rat islet cells stimulated by high glucose was measured by radioemmunoassay. RESULTS: ① No obvious effect was observed of the islet cells with LDL at low glucose level, while the insulin levels decreased in rat islet cells cultured with high glucose. ② Compared with LDL, the insulin levels of glucose stimulating insulin secretion (GSIS) increased in rat islet cells cultured with LDL combined with vitamins E and C for 48 h. CONCLUSION: Uptake of LDL by islet cells and subsequent oxidative reactions can damage the cells. This process can be counteracted by antioxidants. ......

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