大脑皮质__(期刊论文)

小鼠帕金森病模型中的大脑皮质细胞因子表达

http://www.100md.com 《第四军医大学学报》 2005年第13期

大脑皮质,,甲基苯基四氢吡啶；大脑皮质；白细胞介素6；白细胞介素1,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Cytokine alteration of cerebral cortices in murine model of Parkinsons disease

    SHEN YanQin, ZHAO LiChun, LI KangSheng, E. Moze, P.J. Neveu

    1Department of Microbiology and Immunology, Medical College, Shantou University, Shantou 515041, China, 2INSERM U394, Integrative Neurobiologie, Rue de Camille, 33077, Bordeaux Cedex, France

    【Abstract】 AIM: To explore the effects of 1methyl4henyltetrahydropyridine (MPTP) on cerebral cortical cytokines. METHODS: Twentyeight male C57BL/6J mice were treated with 25 mg/kg MPTP i.p. for five consecutive days. The control group (10 mice) were treated with saline. The mice were decapitated on day 1 (10 mice), day 3 (8 mice) and day 14 (10 mice) after the last MPTP injection. IL1β and IL6 levels in supernatant of homogenates of cerebral cortices were measured by the enzyme linked immunosorbent assay (ELISA). RESULTS: MPTP injection affected cerebral cortical IL1β levels (P<0.001) and compared with those in control group, IL1β levels decreased dramatically at day 3 after treatment (P<0.01). MPTP injection had no effect on cerebral cortical IL6 levels. CONCLUSION: MPTP induces IL1β variations in cerebral cortices. ......

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