Effects of different local anesthetics on heart rate variability and pulmonary function during upper thoracic epidural anesthesia

    WANG Tingª²Guo, L¦a Jianª²Rui, XUE Rongª²Liang

    Department of Anesthesia, Second Affiliated Hospital, Xi¬ðan Jiaotong University, Xi¬ðan 710004, China

    ¡¾Abstract¡¿ AIM: To investigate the effects of different local anethestics on the heart rate variability (HRV) and pulmonary function during upper thoracic epidural anesthesia. METHODS: Sixty cases subjected to selective operations under upper thoracic epidural anesthesia were randomly divided into 2 groups: group A (20 g/L chloroprocaine, n=30) and group B (15 g/L lidocaine, n=30). The changes of HR, SBP, DBP, SaO2, HRV, Vc, FVc, FVc1 and MMV before anesthesia and 5, 10, 15, 20, 30 min after anesthesia were recorded and analyzed respectively. RESULTS: HRV, HR, SBP and DBP in group A 5, 10, 15 min after anesthesia decreased significantly compared with those before anesthesia and those in group B (P<0.05). Vc, FVc, FVc1 and MMV at 10 min after anesthesia in both groups decreased significantly compared with those before anesthesia (P<0.05). CONCLUSION: Thoracic epidural anesthesia with both 20 g/L chloroprocaine and 15 g/L lidocaine can reduce sympathetic tension, heart rate and blood pressure. ......